I think its very doable in DV. But the roster that gets you to D4 wont be the one that makes the playoffs there so expect high turnover.
RnG with a C that has 9 JS 9 JR, He'll probably lead your league in 3s as long as your team can get him the ball. then a 3-2 might slow him down when the SF starts covering him but then next game you switch to Push and go inside. You better have 2 guys on your team with 7+ ID or you'll get plowed over.
A SF with range also gets an advantage over most PF that play there out of position. he should have R near your PF and C or you'll lose out on a bunch of rebounds
PG and SG with high driving and IS do really well in Low Post vs guards with low ID
My advice is build your team on paper. How much will your starting 5 make, how much for some subs and trainees. then a list of the realistic skill sets you want at each position on offense then on defense. Then start pairing up offense and defense sets from your list and start shopping. As you shop you can adjust 'realistic skill sets' to get the best the market is offering. It does take patience. In DV you can use old guys because it should be short term. It might take 8 weeks to get most of the pieces together but if your stamina, handling, passing everywhere are 4+ the game engine will find the mismatches you build.