I can tell you that my two DR-proficient, IS-awful guys miss more layups than a respectable, respectable guy and a pitiful, strong guy. It does seem stupid to drive if you have a small chance finishing at the rim, but from what I've gathered a lay up is considered a better opportunity for a high drive player. There are of course many factors like zone D, where you guard end up laying up over a C for ex. so it's hard to measure it. But if you look at FG% among guards with very high DR and poor IS it is quite low.