for strictly follow depth chart it is dependent on stamina, player D will get in the game for whoever has lower stamina of player A, B or C. I haven't tried this reserve pattern but my best guess is that player E will only get minutes if you blow your opponent out and player D will not probably play 3 positions, most likely 2. From my experience combo guard is for 2 positions so if you want D and E to play together player D should only sub for 2 positions you pick, and E will be dedicated to subbing for one position, whichever makes more sense. Unless of course A, B or C gets injured during the game, then this substitution pattern works.